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What is Tick-Borne Encephalitis (TBE) Tick-Borne Encephalitis (TBE) is a viral infection that affects the brain and central nervous system, and is transmitted primarily through the bite of infected ticks. It is caused by the Tick-Borne Encephalitis Virus (TBEV), which belongs to the Flavivirus family.
Duration: ~7 to 14 days (range: 4–28 days)
Symptoms: None (asymptomatic phase)
This is the period after a tick bite but before any symptoms appear.
Duration: 2–7 days
Common symptoms (flu-like):
Fever
Headache
Fatigue
Muscle pain
Nausea
Malaise
Often resolves spontaneously, but in 20–30% of symptomatic patients, the illness progresses after a brief improvement.
Begins ~1 week after initial symptoms subside
Symptoms depend on severity:
Meningitis: headache, stiff neck, sensitivity to light
Encephalitis: confusion, seizures, balance problems
Meningoencephalomyelitis (severe cases): limb weakness, paralysis, especially in older adults
In very severe TBE, especially in older or immunocompromised patients, coma may occur due to brain inflammation and swelling.
Fatality rate:
~1–2% for European subtypes
Up to 20–40% for Far Eastern (Siberian) subtypes
Risk of death increases with age and severity of neurological involvement.
In 10–50% of patients with CNS involvement:
Chronic headaches
Memory problems
Muscle weakness
Coordination issues
Depression or fatigue
Who is most at risk for TBE (Tick-Borne Encephalitis):
People in endemic areas (Eastern/Central Europe, Russia, Asia)
Travelers and hikers in rural/forested zones
Outdoor workers (foresters, farmers, soldiers)
Unvaccinated individuals, especially the elderly and immunocompromised
Children (more frequent contact with nature)
Prevention: Vaccination, protective clothing, repellents, body checks after outdoor activity
✅ Vaccination:The most effective protection. Recommended for people living, working, or traveling in endemic areas (e.g., Central/Eastern Europe, Russia).Given in 2 or 3 doses, with periodic boosters for long-term protection.
🛡️ Protective clothing:Wear long sleeves and pants; tuck pants into socks.
🦟 Repellents:Use products with DEET or permethrin.
🔍 Body check:Check your body and clothes after outdoor activities.
🚫 Avoid high-risk areas:Stay on marked trails, especially from spring to autumn.
There is no specific treatment for TBE once the infection develops.If you are bitten by a tick in an endemic area, you should remove it promptly and monitor for symptoms.
Prevention usually involves:
Vaccination (2–3 doses with boosters for long-term protection).
Protective measures: long sleeves, pants, and tick repellents.
Regular body checks after outdoor activities to remove ticks early.
There is no cure, but it is almost 100% preventable with vaccination. Ticks are most active from spring to autumn, especially in forests and grassy areas
No vaccines found for this disease.
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21 July 2025
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard . Adverse events should also be reported to Bavarian Nordic: drug.safety@bavarian-nordic.com.
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