Rabies

Found on all continents, except Antarctica. It causes ~70,000 deaths globally each year and is nearly 100% fatal once symptoms appear.

What is rabies?

Rabies is a rare but fatal disease caused by a virus that is transmitted to humans from infected animals, usually through a bite or scratch.

The rabies virus attacks the central nervous system and is almost always fatal once symptoms appear.

Each year, this vaccine-preventable disease is responsible for approximately 59,000 deaths globally. That’s approximately one person dying from rabies every 9 minutes. 

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Signs & Symptoms

 

1

Incubation period

Duration: 5 days to 2 years

Virus begins travelling towards the ne

2

 Prodromal

Duration: 0-10 days 

What may occur

  • Fever
  • Nausea and Vomiting
  • Headache
  • Tingling and burning at the site

Symptoms may also include:

loss of appetite, general discomfort, loss of energy

3

 Neurological

Duration: 2-7 days 

What may occur

  • Muscle Weakness
  • Hyper excitability and agitation
  • Confusion and delirium
  • Hydrophobia

Symptoms may also include:

hyperventilation, low blood oxygen, loss of speech, lack of coordination, hallucinations, anxiety, depression, paralysis, throat spasms

4

Coma

Duration: 5-14 days 

What may occur

  • Slow, shallow or interrupted breathing
  • Abrupt loss of heart function
  • Low blood pressure
  • Fluttering or racing heart rate

Symptoms may also include:

pituitary dysfunction

 

5

Death

Duration: 5-14 days 

What may occur

  • Collapsed lungs
  • Blood clots
  • Secondary Infections

Rabies is a fatal disease.

Untreated rabies is almost always fatal, but 100% vaccine-preventable.

Certain groups of people face higher exposure to rabies due to their environment, profession, or lifestyle. These include:

  • Children in endemic regions – more likely to interact with animals and less likely to report bites.

  • Travellers – especially those visiting rural or high-risk areas in Asia and Africa.

  • Veterinarians and animal handlers – frequent contact with potentially infected animals.

  • Laboratory staff – those working with rabies virus or related samples.

  • Communities with limited access to healthcare – where vaccines and post-exposure treatment may not be readily available.

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Rabies is almost always fatal once symptoms appear — but it is 100% preventable with the right measures.

Key prevention strategies include:

  • Vaccination

    • Pre-exposure vaccination: Recommended for travellers, veterinarians, animal handlers, and people in high-risk areas.

    • Post-exposure vaccination: Critical after a potential rabies exposure, such as an animal bite or scratch.

  • Avoid Contact with Stray Animals

    • Do not approach or handle stray dogs, cats, or wild animals, especially in endemic regions.

  • Immediate Wound Care

    • Wash animal bites or scratches thoroughly with soap and water for at least 15 minutes, then seek medical attention immediately.

  • Awareness and Education

    • Public health campaigns, responsible pet ownership, and dog vaccination programmes are essential to reducing rabies worldwide.

Once clinical symptoms of rabies appear, the disease is almost always fatal. This makes rapid treatment after exposure absolutely critical.

Post-Exposure Prophylaxis (PEP)
If a person is bitten, scratched, or licked on broken skin by a potentially rabid animal, they must seek medical care immediately. Treatment typically includes:

  • Wound Cleaning

    • Immediate and thorough washing of the wound with soap and water for at least 15 minutes.

  • Rabies Vaccination

    • A series of rabies vaccine doses given over several weeks to trigger the body’s immune response.

  • Rabies Immunoglobulin (RIG)

    • Administered in severe cases, particularly when the person has not been previously vaccinated, to provide immediate antibodies against the virus.

Rabies Vaccination

A series of rabies vaccine doses given over several weeks to trigger the body’s immune response.

Vaccination

No vaccines found for this disease.

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